Large-scale Proteomics: a Window into Human Aging and Cognitive Decline
How we age and what makes us susceptible to disease is a fundamental question in biology and medicine. We leverage proteomics data from blood and cerebrospinal fluid samples from living people to gain molecular insights into human aging and dementia at the individual level. Hamilton Oh will present work where we discover diverse patterns of organ aging across the population and identify a biomarker that can predict cognitive decline versus resilience in Alzheimer’s disease and Frontotemporal dementia.
Hamilton Oh is a postdoctoral fellow at Icahn School of Medicine at Mount Sinai, co-advised by Scott Russo and Alison Goate. He studies how the brain interacts with the rest of the body in chronic psychological stress and depression. During his PhD, advised by Tony Wyss-Coray at Stanford University, he developed methods to estimate the age of one’s organs using large-scale plasma proteomics and identified cerebrospinal fluid proteins that predict resilience versus susceptibility to Alzheimer’s disease.
This seminar is presented by the The Center for Innovation in Imaging Biomarkers and Integrated Diagnostics (CIMBID) and is open to all members of the Columbia and CUIMC communities. Please register below.
LOCATION
Department of Radiology
622 West 168th Street
PH-1, Suite 317
New York, NY 10032